flowchart TD
A{Crossley et al} --> B(3 months)
A--> C(6 months)
A--> D(12 months)
Kambhampati & Vaishya, 2019
A group of systematic Reviews with meta analysis
Databases: MEDLINE, EMBASE, CINAHL, Scopus, Cochrane CENTRAL, SPORTDiscus
Inclusion criteria: primary ACL injury, aged 18-40 years, with a quantitative measure of quadriceps or hamstring strength
Methodological Quality Assessed on domains outlined by Cochrane Collaboration
Comparison:
A group of systematic Reviews with meta analysis
Databases: MEDLINE, EMBASE, CINAHL, Scopus, Cochrane CENTRAL, SPORTDiscus
Inclusion criteria: primary ACL injury, aged 18-40 years, with a quantitative measure of quadriceps or hamstring strength
Methodological Quality Assessed on domains outlined by Cochrane Collaboration
Comparison:
\[\begin{equation} RoM = \frac{90Nm}{100Nm} \end{equation}\]
Example: ACL Side compared to the contralateral side
ROM = 0.9 95%CI[0.85-0.95]
= ACL side is 0.9x weaker than the contralateral side
= 10% deficit in ACL side strength
Longitudinal/multivariate meta-analysis
Ishak et al 2007, Clinical Trials
Trikalinos & Olkin 2012, Clinical Trials
Cheung 2019, Neuropsychol Rev
Mueskiwa et al 2016, PLOS ONE
Longitudinal/multivariate Meta-Analysis
Allow multiple (correlated) pieces of information from the same study to be included in a meta-analysis
flowchart TD
A{Crossley et al} --> B(3 months)
A--> C(6 months)
A--> D(12 months)
“2-Level”
Random effects for
flowchart TD A[Meta-analysis] --> B(Study 1) A--> C(Study 2) B--> D(i) B--> E(iii) B--> F(iii) C--> G(i) C--> H(iii) C--> I(iii)
“3-Level”
Random effects for
flowchart TD A[Meta-analysis] <--> B(Study 1) A<--> C(Study 2) B--> D(T0) B--> E(T6) D--> F(i) D--> G(ii) D--> H(iii) E--> I(i) E--> J(ii) E--> K(iii) C--> L(T0) C--> M(T6) L--> N(i) L--> O(ii) L--> P(iii) M--> Q(i) M--> R(ii) M--> S(iii)
metafor package.Random effects:
(timepoint | cohort)
Fixed effect: timepoint
Robust variance estimation methods using clubSandwich package 🥪
Is comparing to the contralateral limb equivalent to comparing
to uninjured controls